The correlationship study between the levels of serum Cystatin C and the cognitive dysfunction,the cere-bral perfusion in Alzheimer's diesease patients
10.3760/cma.j.issn.1674-6554.2014.11.010
- VernacularTitle:老年痴呆患者血清胱氨酸蛋白酶抑制剂C与认知功能、脑灌注水平的相关性研究
- Author:
Zhaohui YAO
;
Shaofeng ZHANG
;
Juan LIU
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
Cystatin C;
Encephalatrophy;
Cognitive function;
Cerebral per-fusion
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2014;(11):993-996
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlationship between Cystatin C and the cognitive dysfunction, encephalatrophy and the cerebral perfusion in Alzheimer's disease ( AD ) patients, and to analyze the probable mechanisms of the Cystatin C level alterations. Methods For the 61 male and 55 female AD patients,the levels of Cystatin C,Urea,Cr andβ2?microglobulin were detected by biochemistry analysis.The hypocampus volume and Ev?ans index were measured by MRI imaging. The cerebral perfusion was evaluated by magnetic resonance perfusion imaging of arterial spin labeling technique and image processing. The cognitive level of AD patients was done by MMSE scale and MoCA scale. Results The Cystatin C levels in serum of male AD patients were dramatically dif?ferent from female AD patients(male:(0.95±0.20)mg/L,female:(1.32±0.41)mg/L)(P=0.04). For male AD patients,age and Cystatin C had a correlationship among the hypocampus volume((6157.14±355.58)mm3),Evans index(0.33±0.02),MMSE score(21.66±7.97),and MoCA score(21.96±6.19)(age:P=0.040,0.049,0.035, 0.039;Cystatin C:P=0.035,0.038,0.037,0.035),but for female only age((79.52±8.82)years) had a correla?tionship with the hypocampus volume((6319.53±377.74)mm3),Evans index(0.31±0.02),MMSE score(22.93± 6.22),and MoCA score(23.41±8.20)(P=0.044,0.045,0.047,0.046). For male AD patients,the marked correla?tionship was showed between Cystatin C and the index of cerebral perfusion(P=0.034),but for female patients, there's no correlationship(P=0.086) . Conclusion The Cystatin C level is distinctly different in male and female AD patients. The Cystatin C level in male AD patients maybe be an index to predict the degree of the cognitive dys?function and the level of cerebral perfusion.
