The serum levels of superoxide dismutase, malondialdehyde and nitric oxide in first episode generalized anxiety disorder patients:a control study
10.3760/cma.j.issn.1674-6554.2014.11.012
- VernacularTitle:首发广泛性焦虑患者血清超氧化物歧化酶丙二醛和一氧化氮的对照研究
- Author:
Hui OUYANG
;
Zhiqing GAO
;
Mei JIN
;
Leping XU
- Publication Type:Journal Article
- Keywords:
Generalized anxiety disorder;
Superoxide dismutase;
Malondialdehyde;
Nitric oxide
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2014;(11):1002-1004
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum superoxide dismutase( SOD) ,malondialdehyde ( MDA) , and nitric oxide( NO) level in generalized anxiety disorder ( GAD) patients for exploring the importance of oxida?tive stress in etiology of GAD. Methods 42 cases of first episode patients with GAD ( GAD group) and 42 cases of health ( control group) matched with age and gender were included . Serum levels of SOD,MDA ,and NO were tested to analyze for a control study.Results GAD patients had significantly higher levels of SOD,MAD and NO than health controls ((858.09±137.32)×102 U/L vs (745.40±119.19) ×102 U/L;(10.92±3.42)mmol/L vs (7.52±2.32)mmol/L;(74.32±12.34) μmol/L vs(65.22±14.29) μmol/L), t=4.036,5.368,3.297;P=0.000, 0.000,0.003) . A positive relationship between SOD and total score of Hamilton Anxiety Scale( HAMA ) ,psychotic anxiety factor of HAMA,or somatic anxiety factor of HAMA was found in GAD group ( r=0.331,0.370,0.318;P=0.029,0.016,0.040).The level of MAD correlated with total score or psychotic anxiety factor of HAMA( r=0.311, 0.320;P=0.042,0.039).Conclusion It is suggested that the dysfunction of oxidative stress may play a role in pathogenesis of generalized anxiety disorder.
