Effects of repetitive transcranial magnetic stimulation with theta burst stimulation paradigm on the execu-tive function of schizophrenia patients
10.3760/cma.j.issn.1674-6554.2014.11.011
- VernacularTitle:θ短阵快速脉冲模式重复经颅磁刺激对精神分裂症患者执行功能疗效的研究
- Author:
Lili ZHEN
;
Xingfu ZHAO
;
Xingyan JIANG
;
Feng YI
- Publication Type:Journal Article
- Keywords:
Repetitive Transcranial magnetic stimulate;
Theta burst stimulation paradigm;
Schizo-phrenia;
Executive function;
Event-related potential
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2014;(11):997-1001
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of theta burst stimulation( TBS) paradigm of repetitive tran?scranial magnetic stimulation ( rTMS ) on the treatment of schizophrenia through assessing executive function. Methods 60 patients met with DSM?4 and ICD?10 for schizophrenia disorders criteria were enrolled in this study. The group was divided into theta burst stimulation group(research group, n=30) and sham intervention group ( control group, n=30) . The research group and control group were assessed with the Wisconsin card sorting test (WCST) and the go/no?go task by event?related potential(ERPs) before and after 4 weeks treatment. Each test results of all groups before and after treatment were compared with each other respectively. Results Regarding the WCST test,compared with the baseline,the post?rTMS state of the TBS group showed a decrease in the error selec?tion percentage((59.8±14.7)%),the preservative error number(55.3±18.0) and the preservative error percentage (71.3±12.6)%,but the percentage of conceptual level(71.3±12.6)% increased in the TBS group(P<0.05). Re?garding the go/no?go task by ERPs,compared with the baseline,the post?rTMS statet of the TBS group showed an increase in the no?go P3 amplitude(P<0.05 or 0.01) . After intervention,the score of WCST test and the no?go P3 amplitude were significant differences in TBS group compared with same rTMS group(P>0.05).Conclusions The?ta burst stimulation paradigm of rTMS can improve the executive function in schizophrenic patients.
