Efficacy of duloxetine combined with Bodhi Tree relaxation technique in the treatment of the generalized anxiety disorder and influence of heart rate variability
10.3760/cma.j.issn.1674-6554.2014.11.013
- VernacularTitle:度洛西汀合并菩提树放松治疗广泛性焦虑障碍的疗效及心率变异性的改变
- Author:
Ligang WANG
;
Yueji SUN
;
Aixia CUI
;
Wenheng SUN
- Publication Type:Journal Article
- Keywords:
Duloxetine;
Bodhi Tree relaxation technique;
Generalized anxiety disorder;
Heart rate variability
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2014;(11):1005-1008
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy of duloxetine combined with Bodhi Tree relaxation tech?nique in the treatment of generalized anxiety disorder ( GAD ) and the influence of heart rate variability ( HRV ) . Methods According to the standard of ICD?10,124 GADs were selected as study objects from March 2013 to March 2014. They were randomly divided into intervention group and control group. The intervention group fixedly received duloxetine ( 20 mg/day) and Bodhi Tree relaxation therapy,2 times / week,for 8 weeks;and the control group received only Duloxetine (20 mg/day) treatment. All patients were assessed with SAS,HAMA and Treat?ment Emergent Symptom Scale( TESS) at the baseline and at the end of the 2nd ,4th ,6th ,8th week of the treatment to evaluate the efficacy and side effects. The LF/HF of HRV were observed. Results 1.In both groups,SAS score and HAMA score remarkably decreased after intervention than before treatment( before intervention:control group (63.52±14.25,30.26±11.25) intervention group (64.35±14.33,29.83±10.85);after 8 weeks:control group (30.23±6.68,9.28±3.20) intervention group (25.14±5.59,7.70±2.87), P<0.05). There was statistical signifi?cant between the two groups in the therapeutic effects (χ2=4.09, P<0.05) ,and no significant difference between the two groups on the TESS (P>0.05). 2. The ratio of LF/HF showed significantly decrease in the intervention group than those in the control groupt 13?16=-2.806,-2.725,-3.572,-2.272;P13?16=0.006,0.007,0.001,0.025).The value of anxiety se?verity index and LF/HF was positively correlated ( r=0.342, P<0.05).Conclusion Duloxetine combined with Bodhi Tree relaxation technique can effectively improve the heart rate variability in patients,curative effect is better.
