The expression and clinical significance of serum Golgi protein 73 in hepatocellular carcinoma
- VernacularTitle:肝细胞肝癌患者高尔基体蛋白73血清表达水平及其临床意义
- Author:
Dong WANG
;
Zhu WANG
;
Jianqing ZHANG
;
Jianming LIANG
;
Shihong ZHANG
- Publication Type:Journal Article
- Keywords:
Carcinoma;
HepatocelluLar;
Golgi protein 73
- From:
Journal of Chinese Physician
2014;(z2):4-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of serum Golgi protein 73 in hepatocellular carcinoma(HCC) and analyze the clinical significance.Methods The expression of GP73 was measured by ELISA in 75 HCC ,30 chronic hepatitis and normal con -trols.Results The serum concentrations of GP73 were (128.3 ±33.6)μg/L,(80.3 ±19.2)μg/L and (78.3 ±18.5)μg/L in the HCC, chronic hepatitis patients and normal controls .The serum level of GP73 was significantly higher in HCC than those with chronic hepatitis and healthy controls .GP73 expression was positively correlated with clinical stage , humor size and metastasis.The positive rate of GP73 in stage was 60%,higher than the AFP positive rate(33%).Conclusions The serum level of GP73 is high in HCC and was helpful for distinguishing benign and malignant liver diseases .GP73 can be used as a diagnostic marker for HCC .
