Research on the parameters of oxidative stress in T2DM patients combined with acute coronary syndrome
- VernacularTitle:糖尿病合并急性冠脉综合征老年患者血清氧化应激的研究
- Author:
Ruiliang WANG
;
Zhen SHI
;
Jing CHANG
;
Xiaoxin SHI
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Coronary artery disease;
Acute coronary syndrome;
Oxidative stress
- From:
Journal of Chinese Physician
2014;(z2):32-34
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the variation of the oxidative stress status in type 2 diabetes mellitus(T2DM)patients with acute coronary syndrome (ACS)and significance.Methods Eighty -nine patients hospitalized in our department from September 2012 to April 2014 were divided into three groups: T2DM control (group DM), T2DM with coronary artery disease(group DM-CAD) and T2DM with acute coronary syndrome (group DM-ACS).Blood glucose,HbA1C,Lipids,serum Malondialdehyde (MDA) level, su-peroxide dismutase(SOD) activity, glutathione peroxidase (GSH-Px) activity and total anti-oxidation capacity(T-AOC) were deter-mined.Results Blood glucose、HbA1C and Lipids were similar in three groups ( P >0.05).Compared to group DM and group DM-CAD, serum MDA levels in group DM-ACS were significantly higher( P <0.05), while SOD、GSH-Px activities and T-AOC were sig-nificantly lower than those in group DM and group DM -CAD( P <0.05).Conclusions The oxidative stress level being significantly increased in T2DM patients with ACS.
