The contrast of epalrestat and mecobalamine in improving diabetic peripheral neuropathy
- Author:
Meibiao ZHANG
;
Shuibing YANG
;
Jinjing YANG
;
Xiaoyu LU
;
Wei TANG
;
Zihua LI
;
Li LIU
;
Jianping XIANG
- Publication Type:Journal Article
- Keywords:
Epalrestat;
Mecobalamine;
Diabetic peripheral neuropathy
- From:
Journal of Chinese Physician
2014;(z2):40-43
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the curative effect of Epalrestat and mecobalamine .Methods Epalrestat to treat 48 pa-tionts in DPN and mecobalamine to treat 42,measuring blood sugar ,blood pressure, blood fat and body mass index (BMI) prior and post treatment ,and measuring the MCV and SCV of nervus medianus ,nervus peronaeus connunis and nervus tibialis with EMG .Re-sults The symptom of the two sets have all been improved after the treatment ,and the effective power of Epalrestat and mecobalamine is 92.7% and 80.5% respectively.mean while there is improvement in MCV and SCV of nervus medianus ,nervus peronaeus connunis and nervus tibialis,and is more obvious in the set of Epalrestat ( P <0.01).In the whole process of the treat of the two sets ,no one appear to have adverse reactions .Conclusions Epalrestat has significant curative effect with less adverse reactions , and deserves to be spreaded in clinic.
