Observation of animal model of life cycle of Angiostrongylus cantonensis
- VernacularTitle:广州管圆线虫生活史动物模型的效果观察
- Author:
Jianming WANG
;
Jinjun XU
;
Yonghua ZHOU
;
Jianping TAO
- Publication Type:Journal Article
- Keywords:
Angiostrongylus cantonensis;
Life cycle;
Pomacea canaliculata;
SD rat;
Animal model
- From:
Chinese Journal of Schistosomiasis Control
2014;(6):675-677
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of artificially construction of the life cycle of Angiostrongylus cantonensis in the laboratory condition so as to provide the basis for the research of angiostrongyliasis. Methods SD rats were infected orally with the third?stage larvae of A. cantonensis collected from infected Pomacea canaliculata. Six weeks after the infection the first?stage larvae were isolated and counted from fresh feces of the rats and then were used to infect P. canaliculata. Three weeks lat?er the snails were dissected for counting the third?staged larvae of A. cantonensis. Results The first?stage larvae were detect?ed in the feces of the rats 6 weeks after the infection and the third?staged larvae were successfully isolated after the infection of P. canaliculata. Conclusion The animal model of the entire life cycle of A. cantonensis is successfully established in the labo?ratory with the infection of 50 larvae per rat.
