Expression of brain-type glycogen phosphorylase in human colorectal neoplasia
10.3969/j.issn.1673-4130.2014.23.014
- VernacularTitle:脑型糖原磷酸化酶在人结、直肠肿瘤中的表达
- Author:
Fei TANG
;
Liyun AN
;
Keran JIA
- Publication Type:Journal Article
- Keywords:
brain-type glycogen phosphrorylase;
colorectal neoplasms;
immunohistochemistry
- From:
International Journal of Laboratory Medicine
2014;(23):3187-3189
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of brain-type glycogen phosphorylase(GPBB)as a new biomarker in colorec-tal carcinomas,to understand its expression timing in colorectal neoplasia and its relation with the clinical pathological parameters, and to compare it with the P53 gene.Methods 40 specimens of colorectal carcinoma and 18 specimens of colorecpal neoplasia were selected.The expression of GPBB and P53 in colorectal tumor was investigated by self-made specific anti-human GPBB antibody and P53 antibody.Results The positive expression rate of GPBB in colorectal carcinoma was 80%,which was significantly higher than that in colorectal carcinoma,moreover its expression in moderate and severe atypical hyperplasia adenoma and papillary adenoma was earlier than P53 gene expression.Conclusion GPBB is a enzyme expressed in carcinoma and precancerous lesion,therefore it may be taken as early biomarker enzyme for predicting the occurrence of colorectal carcinoma.
