Aerobic exercise affects c-Src mRNA expression and c-Src activity in aortic vascular endothelial cells of spontaneous hypertensive rat models
10.3969/j.issn.2095-4344.2014.49.013
- VernacularTitle:有氧运动干预自发性高血压模型大鼠主动脉血管内皮细胞c-Src mRNA表达和c-Src的活性
- Author:
Cailing REN
;
Jie QI
;
Jun ZHANG
- Publication Type:Journal Article
- Keywords:
hypertension;
rats,inbred SHR;
proto-oncogenes;
genes,src
- From:
Chinese Journal of Tissue Engineering Research
2014;(49):7943-7947
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Proto-oncogene c-Src plays an important role in regulating cardiovascular diseases such as hypertension. At present, there were no studies concerning exercise intervention effects on c-Src expression in aortic endothelial cels so as to regulate hypertension. OBJECTIVE: To observe the effects of aerobic exercise on c-Src mRNA expression and c-Src activity in the aorta blood vessel endothelial cels of spontaneous hypertensive rats. METHODS: A total of 8 male Wistar rats were considered as normal control group. Sixteen spontaneous hypertensive rats were randomly assigned to 8 rats as spontaneous hypertension group and 8 rats as spontaneous hypertension exercise group. Rats in the spontaneous hypertension exercise group carried on 90 minutes unloaded aerobic swimming every day, 6 days a week, for 8 weeks. The rats in the normal control group and spontaneous hypertension group did not swim. Blood pressure of rats was measured once a week. 8 weeks later, the c-Src mRNA expression and c-Src activity were determined in aortic vascular endothelial cels of rats in each group. RESULTS AND CONCLUSION: Compared with spontaneous hypertension group, blood pressure was lower, but c-Src mRNA expression and c-Src activity were significantly higher in the spontaneous hypertension exercise group. The c-Src activity and c-Src mRNA expression were higher in the spontaneous hypertension exercise group than normal control group and spontaneous hypertension group (P < 0.01). Results indicated that aerobic exercise can promote the increase in c-Src activity and c-Src mRNA expression in aortic endothelial cels of spontaneous hypertensive rats.
