Influence of reversed dipper blood pressure pattern on target organ damage in patients with chronic kidney disease
10.3760/cma.j.issn.1001-7097.2014.12.005
- VernacularTitle:反勺型血压对慢性肾脏病患者靶器官损伤的影响
- Author:
Wenyu GONG
;
Jun ZHANG
;
Hui PENG
;
Xun LIU
;
Tanqi LOU
;
Cheng WANG
- Publication Type:Journal Article
- Keywords:
Renal insufficiency,chronic;
Blood pressure monitoring,ambulatory;
Target organ damage;
Reversed dipper
- From:
Chinese Journal of Nephrology
2014;(12):907-912
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between reversed dipper blood pressure (BP) pattern with target organ damage in Chinese chronic kidney disease (CKD) patients. Methods A total of 1 116 CKD patients from the Third hospital of Sun Yat?sen university were enrolled from May 2010 to April 2014, all of whom carried ambulatory blood pressure monitoring (ABPM), and clinical data and ultrasonography were collected. Results Total of 23.39% CKD patients were reversed dipper BP pattern, 46.95% patients were non?dipper BP pattern, and dipper BP pattern was only 27.15%. Compared with dipper and non?dipper BP pattern group, patients with reversed dipper BP pattern had higher left ventricular mass index (LVMI), lower estimated glomerular filtration rate (eGFR) and severely damaged left ventricular diastolic function (all P<0.0083). After multiple linear regression analysis, reversed dipper BP pattern was an independent predictor for determining eGFR and LVMI. Age, lower hemoglobin and combination of diabetes were independently associated with reversed dipper BP pattern. Conclusion Reversed dipper BP pattern is common in Chinese CKD patients, which is closely related to renal damage and cardiovascular injuries.
