Vacuum sealing drainage technology in combination with multiple factors for treatment of severe soft tissue injury
10.3969/j.issn.2095-4344.2014.47.022
- VernacularTitle:封闭负压引流修复严重软组织损伤：多种因素联合应用的评价
- Author:
Hao LIU
;
Lei SUN
;
Yan QI
;
Ju TIAN
- Publication Type:Journal Article
- Keywords:
drainage;
nerve growth factor;
hyperbaric oxygenation;
chymotrypsin
- From:
Chinese Journal of Tissue Engineering Research
2014;(47):7666-7671
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:The technique of vacuum sealing drainage, initialy used for better wound healing, has been widely applied to al kinds of refractory wounds. OBJECTIVE:To summarize the research progress in vacuum sealing drainage for treatment of severe soft tissue injury. METHODS: An electronic retrieve was performed in Wanfang database, VIP database and PubMed database from January 1989 to August 2014 was performed for papers regarding the vacuum sealing drainage technology with the key words of “vacuum sealing drainage technology; injury; gentamicin; hyperbaric oxygen; nerve growth factor; chymotrypsin” in Chinese or English. Finaly 48 articles were involved in the final analysis according to the inclusion criteria. RESULTS AND CONCLUSION:Vacuum sealing drainage is a highly effective treatment technique to promote wound healing which can promote wound blood circulation, reduce sweling, inhibit bacterial growth, stimulate growth of granulation tissue by mechanical stress, inhibit cel apoptosis, thereby helping wound healing. Compared to conventional open-dressings, vacuum sealing drainage has a faster wound healing speed, lower infection rate, and fewer dressing change frequency. With recent advances in medicine, vacuum sealing drainagetechnology cannot be simply used for treatment of skin soft tissue damage, but in combination with gentamicin, hyperbaric oxygen, nerve growth factor and chymotrypsin to achieve better therapeutic effects.
