Comparison of anesthesia induction efficacy of dexmedetomidine with fentanyl-class drugs in patients un-dergoing awake intubation:a meta-analysis
- VernacularTitle:右美托咪定与芬太尼类药物在清醒气管插管患者麻醉诱导效果比较的 Meta 分析
- Author:
Xiangzhi FANG
;
Yang ZHANG
;
Ju GAO
- Publication Type:Journal Article
- Keywords:
Dexmedetomidine;
Drugs of fentanyl class;
Awake intubation;
Meta-analysis
- From:
The Journal of Clinical Anesthesiology
2014;(12):1175-1180
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically review the efficacy of dexmedetomidine and fentanyl-class drugs for induction in awake intubation patients.Methods We searched the PubMed,Embase, Cochrane library,Wanfang Database,CNKI,VIP and China Biology Medicine (CBM)for all ran-domized controlled trials (RCTs)about the efficacy of dexmedetomidine versus drugs of fentanyl class (fentanyl,sufentanil,remifentanil)for induction in awake intubation patients.The quality of the studies was evaluated by the method recommended by Cochrane Collaboration.Meta-analysis was con-ducted using the Cochrane Collaboration's RevMan 5.0 software.Results Ten RCTs involving 400 patients were included in our Meta-analysis.The results of meta-analysis showed that the ramsay se-dation scores in awake intubation patients was higher in group dexmedetomidine than that of group fentanyl-class drugs (P<0.05).Compared with group fentanyl-class drugs,the incidence of compli-cations such as hypertension,respiratory depression,bucking and post-surgical memory in the group dexmedetomidine was lower (P<0.05).Conclusion The efficacy of dexmedetomidine is better than that fentanyl-class drugs for induction in awake intubation patients.
