Vitreous Vascular Endothelial Growth Factor Concentration In Various Vitreoretinal Disorders.
- Author:
Jung Ah HAN
1
;
Ho Kyun CHO
Author Information
1. Department of Ophthalmology, Pil-Dong Hospital, College of Medicine, Chung-Ang University, Korea. eyedoc98@hotmail.com
- Publication Type:Original Article
- Keywords:
Neovascularization;
VEGF;
Vitreoretinal disorders
- MeSH:
Angiogenesis Inducing Agents;
Enzyme-Linked Immunosorbent Assay;
Hemorrhage;
Humans;
Light Coagulation;
Retinal Detachment;
Retinaldehyde;
Vascular Endothelial Growth Factor A*;
Vitreoretinal Surgery;
Vitreoretinopathy, Proliferative
- From:Journal of the Korean Ophthalmological Society
2002;43(1):96-103
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Vascular endothelial growth factor (VEGF) has been identified as an endothelial cell-specific angiogenic factor of intraocular neovascularization, a pathologic complication of many vitreoretinal disorders. We studied to evaluate clinical correlation of intravitreal VEGF concentration and various vitreoretinal disorders. METHODS: Forty eight vitreous fluid samples were obtained at the time of vitreoretinal surgery from 43 patients of various disorders. Concentrations of VEGF1 6 5 in vitreous fluid were determined by Human VEGF ELISA kit and its correlation with diabetes, intraocular hemorrhage, neovascularization, proliferative vitreoretinopathy, retinal detachment, pan retinal photocoagulation, and postoperative condition was statistically analyzed. RESULTS: Intravitreal concentrations of VEGF in case of intraocular hemorrhage (0.809+/-1.467 ng/ml), neovascularization (1.167+/-1.656 ng/ml), and anterior segment neovascularization (2.381+/-2.043 ng/ml) were significantly high (P<0.05). CONCLUSIONS: VEGF plays a major role in the development of neovascularization in the various retinal disorders.
