Comparison of long-term and short-term mild hypothermia on severe traumatic brain injury:a systematic review
- VernacularTitle:长期亚低温对比短期亚低温治疗重型颅脑损伤的系统评价
- Author:
Xiangqi SONG
;
Tong CHEN
;
Aijun FU
;
Jun ZHU
;
Jianmin LI
;
Yulan JIN
;
Zengbing XIAO
;
Ruigang WANG
- Publication Type:Journal Article
- Keywords:
Mild hypothermia;
Severe traumatic brain injury;
Intracranial pressure;
Meta analysis;
Systematic review
- From:
Journal of Medical Postgraduates
2014;(11):1184-1187
- CountryChina
- Language:Chinese
-
Abstract:
Objective Mild hypothermia provides protection for the brain and improves prognosis in the treatment of severe traumatic brain injury, which is widely acknowledged.The article aimed to analysis the prognosis and complications of long-term and short-term mild hypothermia on patients with severe traumatic brain injury. Methods According to the cochrane systematic review methods, thorough search was carried out in databases including Cochrane, Pubmed, Embase, CBM, CNKI, Wanfang and VIP.Eval-uation was made on the quality of selected documents, and Revman5.2 software was applied for meta analysis after data extraction. Results Long-term mild hypothermia achieved improved prognosis compared to short-term mild hypothermia ( GOS score 4 ~5 ) [RR=1.37, 95%CI (1.14, 1.64), P=0.0006].No significant difference was found between these two therapies in pneumonia in-cidence (P=0.94), arrhythmia incidence ( P=0.54) and stress ulcer incidence (P=0.99). Conclusion In comparison to short-term hypothermia therapy, long-term mild hypothermia therapy improved the prognosis of patients with severe traumatic brain inju-ry without obvious increase in the incidence of pneumonia, arrhythmia and stress ulcer.
