Change of levels of peripheral Th17 cells,IL-17 with Graves′disease before and after 131 I,methimazol treatment
10.3969/j.issn.1000-484X.2015.01.025
- VernacularTitle:Graves病患者131 I、甲巯咪唑治疗前后外周血Th17细胞及IL－17水平的变化
- Author:
Zehua GUO
;
Shipeng YU
;
Bo BAN
- Publication Type:Journal Article
- Keywords:
Graves disease;
Th17 cells;
IL-17;
Pathogenesis;
131 I treatment;
Methimazol treatment
- From:
Chinese Journal of Immunology
2015;(1):117-121
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the role of Th17 cells in the pathogenesis with Graves′disease (GD),through examining the proportion of peripheral of Th17 cells and the plasma levels of Interleukin-17 ( IL-17 ) before and after 131 I or methimazol ( MMI ) treatment with GD patients.Methods:We studied 31 subjects and 30 subjects with GD after 131 I or MMI treatment as 131 I therapy group and MMI therapy group and examined as before treatment (T0 ),one month (T1)and three months (T3)after the treatment.29 age-and sexmatched healthy subjects were enrolled as the healthy control group.The Th17 lymphocytes cells were investigated by flow cytometry analysis.The levels of serum IL-17 were measured by ELISA.Results:The proportion of peripheral Th17 cells and the levels of IL-17 were significantly increased in the T0 group GD patients compared with the control group( P<0.01).In the 131 I therapy group the levels of Th17 cells,IL-17 in T0,T1,T3 decreased gradually,but still higher than in normal group( P<0.01) .But there was no sig-nificant difference in MMI therapy group (P>0.05).The proportion of peripheral Th17 cells had positive relationship with the level of IL-17( r=0.758,P<0.05 ) .Both of them were associated positively with thyroid autoantibodies.Conclusion: Th17 cells, IL-17 are highly expressed in the GD.Th17 cells may play an important role in the pathogenesis of GD.In addition,radioactive 131 I may also work on GD via Th17 cells and IL-17.
