Pharmacodynamic study on antitussive, antiasthmatic and expectorant effects of Jizhipingchuan soft capsula
- VernacularTitle:急支平喘软胶囊的镇咳平喘化痰药效研究
- Author:
Li LI
;
Wenya LIU
;
Zhonghua HOU
- Publication Type:Journal Article
- Keywords:
Jizhipingchuan soft capsula;
Antitussive;
Antiasthmatic;
Expectorant
- From:
Journal of Medical Postgraduates
2014;(11):1194-1196
- CountryChina
- Language:Chinese
-
Abstract:
Objective Jizhipingchuan soft capsula is mainly used to treat acute bronchitis and acute attack of chronic bron-chitis.This paper investigate the antitussive, antiasthmatic and expectorant effects of Jizhipingchuan soft capsula according to its func-tions. Methods The antitussive effect of Jizhipingchuan soft capsula was observed in cough mouse model induced by ammonia and in guinea cough pig model induced by citric acid, and the latent period of asthma was observed in guinea pig induced by acetylcholine chloride and histamine phosphate.Its expectorant effect was evaluated by the excretion of phenol red in mice and the exudation phlegm in rats. Results Jizhipingchuan soft capsula could decrease the frequence of cough induced by ammonia in mice and induced by cit-ric acid in guinea pig.It could prolong the latent period of cough in guine pig and also prolong the latent period of asthma in guine pig induced by acetylcholine chloride and histamine phosphate.Jizhipingchuan soft capsula could significantly increase the amount of phe-nol red secreted in mice and the phlegm exudation of rats. Conclusion Jizhipingchuan soft capsula showed definite antitussive, an-tiasthmatic and expectorant effects.
