Regulation and significance of acidification of plasma membrane and intracellular membranes
- VernacularTitle:细胞质膜及内膜酸化作用的调控及意义
- Author:
Haiying HU
;
Weijing LIU
;
Huafeng LIU
- Publication Type:Journal Article
- Keywords:
Vacuolar ATPases;
Chloride channel;
Acidification
- From:
Journal of Medical Postgraduates
2014;(11):1223-1225
- CountryChina
- Language:Chinese
-
Abstract:
Acidic environment of organelles of eukaryotic cells plays an important role in endocytosis, the secretion of lysoso-mal enzymes and other physiological activities.V-ATPase (vacuolar ATPases) and CLC (chloride channel) family are widely distribu-ted and present in virtually all eukaryotic cells in intracellular membranes and in the plasma membrane.They are responsible for the a-cidification of the vesicular interior.In this paper, the distribution, structure, mechanism of action and physiological and pathological significance of V-ATPase and CLC protein are discussed.
