Correlation of serum procalcitonin and prognosis of neonatal sepsis
10.3760/cma.j.issn.1008-6706.2014.23.015
- VernacularTitle:血清降钙素原水平与脓毒血症预后的相关性研究
- Author:
Guangming XIANG
;
Baoan GAO
- Publication Type:Journal Article
- Keywords:
Procalcitonin;
Septicemia;
Prognosis;
Relevance
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(23):3558-3560
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation of serum procalcitonin and prognosis of neonatal sepsis. Methods 113 cases of infection were selected as the objects of study,which were divided into the observation group ( sepsis) and control group ( non sepsis) according to the presence of sepsis.2mL venous blood was selected when patients were admitted to hospital before antibiotic treatment.The level of PCT was detected by immunoluminometric assay.PCT level at admission and after treatment were used to analyze the relationship between changes and the severity and prognosis of patients.Results PCT level of the observation group [(11.03 ±6.21)ng/mL] were higher than that of the control group [(0.81 ±1.61)ng/mL] (t=8.507,P<0.01),Sepsis and death in patients with serum PCT values increased significantly over time (F=5.061,P<0.05);invalid value of serum PCT in patients with disease exacerbation was significantly higher(F=4.793,P<0.05);improved serum PCT values in patients with the disease better reduced(F=6.009,P<0.05).While PCT<14.86ng/mL mortality rate (14.89%) was significantly lower than the PCT≥14.86ng/mL mortality rate (72.22%).Conclusion PCT shows important clinical efficacy in forcasting prognosis of neonatal sepsis.It is worthy of wider promotion and application.
