Correlation between pulmonary quantitative indicators on high-resolution CT and pulmonary function in patients with chronic obstructive pulmonary disease
10.3760/cma.j.issn.1008-6706.2014.23.004
- VernacularTitle:慢性阻塞性肺疾病患者呼吸双相高分辨率 CT肺定量指标与肺功能的相关性研究
- Author:
Changcun SHI
;
Weishao AN
- Publication Type:Journal Article
- Keywords:
Pulmonary disease,chronic obstructive;
Tomography,X-ray computed;
Lung function
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(23):3529-3532
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between pulmonary quantitative indicators on 64-slice spiral CT and lung function,and the diagnosis value of breathing bipolar lung CT scan to emphysema.Methods 54 chronic obstructive pulmonary disease patients were divided into the mild group ( n =5 ) , moderate group ( n =21 ) , severe group(n=19) and gravely severe group(n=9).Four groups received breathing bipolar total lung high-resolution CT scan to test lung density at the end of deep inspiration and expiration,breathing bipolar lung density difference and lung volume,and the relationship between lung density/volume and lung function indicators were analyzed.Results There were significant differences in lung density at the end of deep inspiration and expiration(t=13.67,9.89,all P<0.05),the forced expiratory volume in one second(FEV1),forced vital capacity(FVC)and FEV1/FVC among these fourgroups(t=1.15,0.89,7.89,13.76,16.67,all P<0.05).The lung volume at the end of inspiration and expiration increased with the severity of disease,while there were no significant differences among these four groups (t=15.46,13.28,11.47,all P>0.05).The lung volumes at the end of deep inspiration and expiration were obvi-ously correlated with FVC,FEV1 and FEV1/FVC(r=-0.071,-0.083,r=-0.713,-0.542,r=-0.622,0.639, all P<0.05) .The lung volume at the end of deep expiration was obviously correlated with the expected ratio of resid-ual volume to maximum total lung capacity(r=0.622,P<0.05).The deep aspiratory phase lung density was closely correlated with FEV1/FVC and residual volume(r=0.539,P<0.05).Conclusion Pulmonary quantitative indica-tors on 64-slice spiral CT and pulmonary function has good correlation,which can be used to evaluate the severity of emphysema in patients with chronic obstructive pulmonary disease.
