18F-FDG PET/CT in Differential Diagnosis of Incidental Benign or Malignant Thyroid Focal Hypermetabolic Lesions
10.3969/j.issn.1005-5185.2014.11.003
- VernacularTitle:18F-FDG PET/CT对偶发甲状腺局灶性高代谢灶良恶性的诊断价值
- Author:
Haifeng GAO
;
Hongjuan CHEN
;
Yanqi ZHANG
;
Ying QIAO
- Publication Type:Journal Article
- Keywords:
Thyroid neoplasms;
Positron-emission tomography;
Tomography,X-ray computed;
Fluorodeoxyglucose F18;
Image processing,computer-assisted
- From:
Chinese Journal of Medical Imaging
2014;(11):811-814
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the significance of PET/CT in differential diagnosis of incidental thyroid benign or malignant lesions with high fluorodeoxyglucose (FDG) uptake.Materials and Methods Forty cases with focal high FDG uptake lesion in thyroid accidently detected by PET/CT were retrospectively collected. The subjects were dived into physiological uptake group (n=18), benign lesion group (n=16) and malignant lesion group (n=6) according to the pathology or follow-up examinations. The average SUVmax of different groups was analyzed, and ROC curve was used todetect benign or malignant lesions.Results The average SUVmax was 3.7±1.1 in physiological uptake group, 4.9±2.3 in benign lesion group and 9.5±4.8 in malignant lesion group. Significant difference was noticed among the three groups. The average SUVmax in malignant lesion group was higher than that of the other two groups with statistical difference (P<005). No significant difference was observed between physiological uptake group and benign lesion group (P>0.05). ROC analysis showed that the sensitivity and specificity for thyroid malignant tumor were 100.0% and 87.2% at SUVmax of 8.5.Conclusion18F-FDG PET/CT plays an important role in differentiating benign lesions of thyroid from malignance, but it is not helpful to identify benign lesions from physiologic uptake.
