The correlation between copeptin and clinical severity and prognosis in acute cerebral infarction
10.3969/j.issn.1671-8348.2014.32.020
- VernacularTitle:和肽素与急性脑梗死病情及近期预后的关系
- Author:
Yun WANG
;
Jinxia CAO
;
Jiandong JIANG
;
Qinghong ZENG
- Publication Type:Journal Article
- Keywords:
acute cerebral infarction;
copeptin;
infarction severity;
prognosis
- From:
Chongqing Medicine
2014;(32):4335-4337
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the ability of copeptin to predict infarction severity and prognosis after 3 months in patients with acute cerebral infarction .Methods One hundred and thirty‐eight consecutive patients were included with an acute cerebral in‐farction and admitted to the hospital within 72 h .Plasma copeptin levels were measured by double antibody enzyme linked immu‐nosorbent assay and neurological impairment were evaluated by the national institutes of health stroke scale score (NIHSS) after hospitalization .The patients were divided into mild ,moderate and severe groups according to NIHSS score .At the same time ,60 healthy adults were selected as control group .Unfavorable outcome was defined as a modified rankin scale score>2 .The correlation of plasma copeptin levels with 3 month unfavorable outcome was analyzed .Results Upon admission ,plasma copeptin level in pa‐tients was statistically significantly higher than that in healthy controls (P<0 .01) ,the highest was found in severe subgroup (P<0 .05) .Multivariate logistic regression analysis revealed that copeptin was independently associated with unfavorable outcome within 3 months (OR=4 .403 ,95% CI:1 .120-8 .328 ,P<0 .05) .Conclusion Copeptin levels contribute to mirror the initial infarction se‐verity and even bear an association with poor outcome of patients with cerebral infarction within 3 months .
