The role of saccharomyces cerevisiae DRE2 in endoplasmic reticulum stress response
10.3969/j.issn.1671-8348.2014.31.018
- VernacularTitle:DR E2基因参与酵母内质网应激调控机制的初步研究
- Author:
Wei ZHAO
;
Yujie NIU
;
Yuan YUAN
;
Xinguang LIU
- Publication Type:Journal Article
- Keywords:
DRE2;
saccharomyces cerevisiae;
endoplasmic reticulum response
- From:
Chongqing Medicine
2014;(31):4172-4174
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the role of saccharomyces cerevisiae DRE2 in endoplasmic reticulum response induced by tunica‐mycin .Methods The der2 ::URA3 gene deletion cassette was amplified from the wild type genomic DNA by PCR ;DRE2 deficiency heterozygote strain was made by gene recombination .The heterozygote strain resistant ability to tunicamycin and the replicative li‐fespan were analyzed in this study .Results DRE2 deficiency strain was resistant to tunicamycin ,but the replicative lifespan was decreased compared to wild type strain (P< 0 .05) .Conclusion DRE2 may be involved in the yeast endoplasmic reticulum response and replicative lifespan regulation .
