Hemodynamic changes on right ventricular hypertrophy induced by monocrotaline in rats
10.3969/j.issn.1671-8348.2014.32.007
- VernacularTitle:野百合碱致心肌肥厚大鼠的右心室血流动力学变化研究
- Author:
Can LUO
;
Lan HUANG
- Publication Type:Journal Article
- Keywords:
monocrotaline;
hemodynamics;
rats;
hypertrophy;
right ventricle
- From:
Chongqing Medicine
2014;(32):4294-4296
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the hemodynamic changes on right ventricular hypertrophy induced by monocrotaline in rats . Methods Male SD rats were given monocrotaline 60 mg/kg by a single intraperitoneal injection ,the mRNA expression of RV/BW , RVHI and ANF were took as the indicators .Intraperitoneal injection with 10% chloral hydrate was performed ,the artery cannulae and right ventricular catheter were inserted ,and the right ventricle pressure was measured .Results The RVHI and RV/BW were significantly increased in M2W and M4W groups ,compared with vehicle control (P<0 .01) ,and the ANF mRNA expression was significantly increased in both groups .Bp and HR did not change in model groups .RVEDP markedly decreased (P< 0 .01) and RVP ,± dp/dtmax ,t dp/dtmax and Vpm increased (P<0 .001) in M2W groups ;and all parameters increased significantly in M4W groups (P<0 .01) .Conclusion Monocrotaline can induce RVH ,which accompany hemodynamic changes and the systolic and dias‐tolic dysfunction in right ventricle may eventually cause right heart failure .
