Effect of uric acid reduction on blood pressure in hypertensive patients with asymptomatic hyperuricemia
10.3969/j.issn.1671-8348.2014.32.017
- VernacularTitle:降尿酸治疗对伴发无症状高尿酸血症的高血压患者血压的影响
- Author:
Yifa ZHAO
;
Zhonglin XU
- Publication Type:Journal Article
- Keywords:
hypertension;
hyperuricemia;
uric acid;
blood pressure
- From:
Chongqing Medicine
2014;(32):4326-4328
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of the reduction of serum uric acid(SUA) on blood pressure(BP) control and re‐nal function protection in hypertensive patients with asymptomatic hyperuricemia (HUA) .Methods One hundred and forty‐eight hypertensive patients with asymptomatic HUA were randomly divided into two groups ,namely HUA reduction group and control group .Patients in HUA reduction group was provided with benzbromarone and low purine food ,while patients in control group was given placebo and ordinary diet .All patients were given the same method of antihypertensive drugs .Follow up was preformed for 6 months ,data of BP ,SUA ,creatinine(Cr) ,creatinine clearance(Ccr) ,24 h microalbuminuria quantity(MAU) ,serumβ2 microglobulin (β2‐MG)and adverse reactions were recorded and analyzed .Results The systolic blood pressure(SBP) and diastolic blood pressure (DBP) of patients in HUA reduction group significantly decreased immediately after being treated ,while SUA decreased 1 month after being treated .Compared with control group ,the average SBP and DBP of patients in HUA reduction group was significantly lower 3 months after being treated;the SUA was significantly lower 1 months after being treated ,the levels of Cr ,Ccr ,MAU andβ2‐MG was significantly lower at 3 months and 6 months after being treated (P<0 .05) .Conclusion The SUA therapy can effec‐tively lower BP and SUA levels of primary hypertensive patients with asymptomatic HUA while protecting renal function .
