Effect of esmolol on myocardial apoptosis and cardiac function in rats with sepsis
10.3969/j.issn.1671-8348.2014.31.021
- VernacularTitle:艾司洛尔对脓毒症大鼠心肌细胞凋亡及心功能的影响
- Author:
Dehong LIU
;
Yingfeng LIU
;
Xinke MENG
;
Zhiwei XU
- Publication Type:Journal Article
- Keywords:
sepsis;
apoptosis;
esmolol;
cardiac function
- From:
Chongqing Medicine
2014;(31):4181-4184
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of esmolol on myocardial apoptosis and cardiac function in rats with sepsis .Meth‐ods Ninety six SD rats were randomly divided into sham group (n= 32 ,for sham operation) ,sepsis group (n= 32 ,sepsis model) and treatment group (n= 32 ,intravenous infusion with esmolol after sepsis modeling) .At 3 h ,6 h ,12 h ,24 h after operation ,sam‐ples were conserved to measure serum cardiac troponin I (cTnI) ,caspase‐3 ,cardiomyocytes apoptosis index ,and myocardial patho‐morphology was observed by optical microscope .At 24 h after operation ,echocardiography was performed .Results The serum cT‐nI ,caspase‐3 ,cardiomyocytes apoptosis index were increased significantly in sepsis group and treatment group compared with sham group (all P< 0 .05) .After using esmolol ,cTnI and cardiomyocytes apoptosis index were relatively decreased in treatment group compared with sepsis group at the four time‐points(all P < 0 .05) .Caspase‐3 of treatment group decreased at 12 h after operation compared with sepsis group (P< 0 .05) .Treatment group had a higher LVEF than sepsis group at 24 h(P< 0 .05) .Conclusion Es‐molol could inhibit myocardial apoptosis and mitigate the damage of cardiac function in rats with sepsis .The decrease in caspase‐3 may be the mechanism of anti‐apoptosis .
