Clinical application of the detection of sIgE and sIgG4 in children with allergic diseases
10.3969/j.issn.1673-4130.2014.22.003
- VernacularTitle:血清sIgE和sIgG4检测在儿童过敏性疾病中的临床应用
- Author:
Meng GU
;
Cuijun DING
;
Dongming LU
;
Chunbiao GAO
;
Chao CHEN
- Publication Type:Journal Article
- Keywords:
specific IgE;
specific IgG4;
allergic asthma;
allergic rhinitis
- From:
International Journal of Laboratory Medicine
2014;(22):3013-3014
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical application value of the detection of sIgE and sIgG4 in children with allergic asthma and allergic rhinitis .Methods The levels of sIgE and sIgG4 of allergic asthma group (n=85) ,allergic rhinitis group (n=72) and control group (n=60) were respectively detected by ELISA .The diagnostic efficiency of sIgE and sIgG4 were analyzed by using ROC curve .Results Before treatment ,the serum levels of sIgE and sIgG4 of allergic asthma group and allergic rhinitis group were remarkably higher than those of control group (P< 0 .01) .After 6 -month treatment ,the serum sIgE levels of allergic asthma group and allergic rhinitis group significantly decreased ,and the serum sIgG4 levels significantly increased (P< 0 .01) .For the combined detection of sIgE and sIgG4 ,the diagnostic sensitivities of allergic asthma and allergic rhinitis were 90 .6% (77/85) and 84 .7% (61/72) respectively ,and the diagnostic specificities of allergic asthma and allergic rhinitis were 81 .2% (69/85) and 76 .4%(55/72) respectively .Conclusion The serum sIgE and sIgG4 are good indicators for the diagnosis of allergic diseases .
