Expression and clinical significance of telomerase and hTERT in ovarian neoplasm tissues
10.3969/j.issn.1673-4130.2014.22.014
- VernacularTitle:端粒酶及hTERT在卵巢肿瘤组织中的表达及其临床意义
- Author:
Ling LI
;
Mingshui XIE
;
Yang LIU
- Publication Type:Journal Article
- Keywords:
telomerase;
hT ERT;
ovarian neoplasm
- From:
International Journal of Laboratory Medicine
2014;(22):3038-3039
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the expression and clinical significance of telomerase and hTERT in ovarian neoplasm tissues . Methods The activities of telomerase and the expression levels of hTERT mRNA were detected in the tissues of malignant ovarian neoplasm ,benign ovarian neoplasm and normal ovarian respectively ,and the results were analyzed .Results Comparing with the tis‐sues of benign ovarian neoplasm and normal ovarian ,the activity of telomerase and the expression level of hTERT mRNA increased in malignant ovarian neoplasm tissues ,and the differences were statistically significant(P< 0 .05) .Conclusion The telomerase plays an important role in the occurrence and development of malignant ovarian neoplasm .The detection of telomerase activity can help in early diagnosis of malignant ovarian neoplasm .
