Value of combined utilization of urinary CysC and NAG in the diagnosis of renal tubules damage

VernacularTitle:尿液胱抑素C与β-N-乙酰氨基葡萄糖苷酶联合检测对肾小管损伤的诊断价值
Author: Zhi ZHANG ; Qiao SHU ; Yuehua LIAO
Publication Type:Journal Article
Keywords: cystatin C; β-N-acetyl-glucosaminidase; renal tubular damage; urine
From: International Journal of Laboratory Medicine 2014;(22):3053-3054
CountryChina
Language:Chinese
Abstract: Objective To discuss the diagnostic value of combined utilization of urinary cystatin C (CysC) and β‐N‐acetyl‐glu‐cosaminidase (NAG) in renal tubules injury .Methods Urine samples were collected from 130 cases of patients with renal tubular damage (case group) and 100 cases of health individuals (normal control group) ,respectively .The concentration of CysC and the activity of NAG in urine were detected .Results The sensitivity ,specificity ,and positive predictive value of combined utilization of CysC and NAG in diagnosis of renal tubules damage were 85 .4% ,89 .6% and 82 .1% ,respectively .The concentration of CysC and the activity of NAG in case group after treatment were both significantly different from those before treatment (P<0 .05) .Conclu‐sion Combined utilization of urinary CysC and NAG has a significant value for the diagnosis and the therapeutic monitoring in re‐nal tubules injury .