Research on the diagnostic values of the detection of urine exfoliated cells by FISH and cytologic technology in bladder urothelial tumor

VernacularTitle:FISH技术及细胞学技术检测尿脱落细胞对膀胱尿路上皮肿瘤诊断价值研究
Author: Wei CHEN ; Huixia YI ; Rui ZHANG
Publication Type:Journal Article
Keywords: fluorescence in situ hybridization; exfoliated cells; cytologic diagnose; urothelial tumors; bladder
From: International Journal of Laboratory Medicine 2014;(22):3094-3096
CountryChina
Language:Chinese
Abstract: Objective To compare the diagnostic values of the detection of urine exfoliated cells by FISH and cytology technolo‐gy in bladder urothelial tumor .Methods The combination probes of CSP3/CSP7 and GLPp16/CSP17 were both used in the FISH detection of urine exfoliated cells from suspected patients with bladder urothelial tumor .The urine exfoliated cells were detected by cytology technology at the same time .The sensitivity and the specificity of the two methods were compared .Results The sensitivi‐ty and specificity of FISH for bladder urothelial tumor screening were 92 .5% and 85 .0% respectively ,and those of cytology tech‐nology were 27 .5% and 90 .0% respectively .The sensitivity of FISH was significantly higher than that of cytology technology (P<0 .05) ,however ,the specificity differences between FISH and cytology technology were not statistically significant (P>0 .05) .Conclusion FISH is expected to become a new method for the screening of bladder urothelial tumor .