A Study on Regularity of Compound Herbal Formulae for Renal Fibrosis Based on Literature

VernacularTitle:基于文献的中药复方治疗肾纤维化用药规律研究
Author: Li QI ; Tao YI ; Xiaoning WANG ; Ping LIU ; Chenghai LIU
Publication Type:Journal Article
Keywords: renal fibrosis; compound herbal formula; frequency analysis; cluster analysis; association rule; data mining
From: Chinese Journal of Information on Traditional Chinese Medicine 2014;(12):34-37
CountryChina
Language:Chinese
Abstract: Objective To study the regularity of compound herbal formulae for renal fibrosis (RF). Methods Compound herbal formulae published about the treatment of RF in databases of Chinese Science and Technology Periodical Database, CNKI, Chinese Biomedical Literature Service System, and Wanfang Databasewere searched and collected. A database was established for data mining by using frequency analysis, cluster analysis and association rule analysis. Regularity of key herbs and groups of herbs was discussed. Results There were 38 prescriptions (totally 95 herbs) in the compound herbal formulae for RF, and the total frequency was 362 times. High frequency herbs under cluster analysis were classified into 3 clusters including tonic, hemorheologic agent and promoting diuresis drugs. The rules in pair of herbs were 18, and rules in group of herbs were 31 (three or four medicinal herbs) by using association rule analysis. Conclusion Tonifying promoting blood circulation and removing blood stasisis a common sense for treating RF.