A Preliminary Study on Anti-inflammatory Effects of Rhamnocitrin from Oxytropis falcata Bunge
10.3969/j.issn.1005-5304.2014.12.014
- VernacularTitle:镰形棘豆中鼠李柠檬素抗炎作用研究
- Author:
Qiuli GU
;
Conglin HUANG
;
Li ZHANG
;
Hua JIANG
- Publication Type:Journal Article
- Keywords:
Oxytropis falcata Bunge;
rhamnocitrin;
anti-inflammatory effect;
animal model
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(12):48-50
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the anti-inflammatory effects of rhamnocitrin in Oxytropis falcata Bunge;To provide experimental evidence for searching the anti-inflammatory active component of Oxytropis falcata Bunge. Methods Kunming mice or Wistar rats were randomly divided into model group, naproxen group and rhamnocitrin high-, medium-, low-dose groups, and corresponding medicines were administered by gavage for 7 days. Animal inflammatory models were established respectively by the mice ear swelling induced by dimethylbenzene, the mice abdominal capillary permeability induced by acetic acid, the rat paw edema created by injection of albumen and the rat granuloma induced by cotton pellet wool. The effects of rhamnocitrin on acute and chronic inflammatory animal models were observed. Results Different doses of rhamnocitrin groups could reduce the animal ear swelling, abdominal capillary permeability, paw edema and granuloma. Compared with the model group, there were obvious differences in rhamnocitrin groups (P<0.05). High dose rhamnocitrin group and naproxen group showed relatively strong inhibition effects on swelling, with statistical significance (P<0.05). Conclusion Rhamnocitrin has anti-inflammatory effects and is an important biological component of Oxytropis falcata Bunge.
