Determination of Imatinib Mesylate Liposome and Related Substances by HPLC
10.3870/yydb.2014.11.026
- VernacularTitle:高效液相色谱法测定甲磺酸伊马替尼脂质体含量及有关物质
- Author:
Xiaqin FANG
;
Mengmeng LIU
;
Xiuli ZHANG
;
Yifei WU
;
Wensheng ZHENG
- Publication Type:Journal Article
- Keywords:
Imatinib,mesylate;
Determination;
Related substances;
HPLC
- From:
Herald of Medicine
2014;(11):1496-1498
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a method for determination of imatinib mesylate liposome and related substances. Methods The liquid chromatography was carried out on a Kromasil C18 column. The mobile phase A consisted of methanol-octane sulfonate solution(42:58). The mobile phase B consisted of methanol-octane sulfonate solution(4:96). The flow rate of gradient elution was 1. 2 mL·min-1 . The detection wavelength was 268 nm. The column temperature was room temperature. Results The intermediates and degraded substances could be seperated under the selected chromatographic conditions. Imatinib mesylate showed a good linear relationship within 1-100μg·mL-1,r=0. 999 1(n=5). Conclusion The method is specific, accurate,sensitive,and simple,and can be used for quality control of imatinib mesylate liposome.
