Stability of Jinyin Qingre Oral Liquid
10.3870/yydb.2014.11.028
- VernacularTitle:金茵清热口服液稳定性考察
- Author:
Zegan LIU
;
Liangyong HUANG
;
Haitao ZHU
;
Shiming DU
- Publication Type:Journal Article
- Keywords:
Jinyin qingre oral liquid;
Stability;
Stress test;
Accelerated test
- From:
Herald of Medicine
2014;(11):1502-1505
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the stability of jinyin qingre oral liquid. Methods According to the stability test guidelines for pharmaceutical preparations,the appearance,pH and relative density of jinyin qingre oral liquid were detected, the contents of geniposide,chlorogenic acid and salvia acid B were determined by HPLC. The chromatographic conditions were as follows:AtlantisT3 column(150 mm×4. 6 mm,3 μm),mobile phase A:0. 05% phosphoric acid,mobile phase B:acetonitrle, gradient elution at the flow rate of 0. 8 mL · min-1 ,and column temperature at 35 ℃. The detection wavelength was set at 254 nm. Results The appearance,pH,and relative density of jinyin qingre oral liquid did not change significantly with the acceleration test,but the contents of geniposide,chlorogenic acid and salvia acid B decreased time dependently. Conclusion Light and high temperature could decrease the stability of the jinyin qingre oral liquid.
