Procalcitonin diagnostic value in infection in intensive care unit patients

VernacularTitle:重症监护室感染患者降钙素原诊断价值研究
Author: Youquan ZHOU ; Yanzhang GAO ; Xiyan ZHANG ; Yu HU ; Yuming WANG
Publication Type:Journal Article
Keywords: intensive care unit; procalcitonin; infectious disease; diagnostic test; sensitivity; specificity
From: Chinese Journal of Infection Control 2014;(12):733-735
CountryChina
Language:Chinese
Abstract: Objective To evaluate diagnostic value and clinical significance of procalcitonin (PCT)in infection in intensive care unit (ICU)patients.Methods 96 ICU patients in a hospital between September 2011 and March 2012 were selected for study,levels of patients’PCT,high-sensitivity C-reactive protein (HsCRP)and white blood cell (WBC)count were detected,statistical analysis were conducted.Results Compared with non-bacteria infected patients,serum PCT and HsCRP levels in all bacteria infected patients increased,the difference were significant (Z=-6.102;-3.918,both P <0.05 );WBC count was not significantly different(Z =0.212.P >0.05).PCT sensi-tivity,specificity,positive predictive value,and negative predictive value for diagnosing infection was 82.35%, 67.86%,86.15%,and 61 .29% respectively;receiver operating characteristic (ROC)curve of PCT,HsCRP,and WBC was 0.898,0.755,and 0.581 respectively.Conclusion There are higher sensitivity and specificity of PCT to predict infection,which is helpful for early detection of infection in critically ill patients.