Advances in Study on Brain-gut Axis Dysfunction in Pathogenesis of Irritable Bowel Syndrome
10.3969/j.issn.1008-7125.2014.11.012
- VernacularTitle:脑-肠轴失调在肠易激综合征发病中作用的研究进展
- Author:
Lei ZHANG
;
Jun SONG
;
Xiaohua HOU
- Publication Type:Journal Article
- Keywords:
IrritabIe BoweI Syndrome;
Brain-GutAxis;
Neurosecretory Systems;
Stress
- From:
Chinese Journal of Gastroenterology
2014;(11):688-691
- CountryChina
- Language:Chinese
-
Abstract:
IrritabIe boweI syndrome( IBS)is caused by muItipIe factors,and the pathogenesis has not yet been cIarified. RecentIy,the roIe of brain-gut axis based bio-psycho-sociaI medicaI modeI in the pathogenesis of IBS has been wideIy accepted. Brain-gut axis forms a nerve-endocrine-immune network mediating bidirectionaI reguIation pathway,which pIays an important roIe in maintaining homeostasis between centraI nervous system and gut. Brain-gut axis abnormaIities may Iead to imbaIance of the homeostasis and subsequentIy induce the occurrence of IBS. This articIe reviewed the advances in study on brain-gut axis dysfunction in pathogenesis of IBS.
