Correlation among angiotensinogen gene polymorphisma,blood glucose level and atherosclerotic cerebral infarction
10.3969/j.issn.1673-4130.2014.24.028
- VernacularTitle:血管紧张素原基因多态性及血糖水平与动脉硬化性脑梗死的相关性
- Author:
Hongfen LI
;
Zhixia SHEN
;
Zihong LIU
;
Yingjie WANG
;
Jie AN
;
Yan REN
- Publication Type:Journal Article
- Keywords:
atherosclerotic cerebral infarction;
angiotensinogen;
genepolymorphism;
blood glucose
- From:
International Journal of Laboratory Medicine
2014;(24):3364-3365
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship among the angiotensinogen (AGT)gene T174M,M235T polymorphisma,blood glucose level and atherosclerotic cerebral infarction.Methods The polymerase chain reaction-restriction fragment length polymor-phism (PCR-RFLP)method was adopted to detecte the gene polymorphisms of AGT gene 174,235 sites and the fully automatic bi-ochemical analyzer was used to detect the biochemical indexes of GLU,etc.in 396 patients with atherosclerotic cerebral infarction and 360 normal controls.Results The GLU level in the patients of the ACI group carrying genotype TT and TM at AGT gene T174M site was higher than that in the normal control group with statistical differences(P <0.05),the glucose level had no statisti-cal difference between the different 2 kinds of genotype (P >0.05);the glucose level in the patients carrying genotypes MM,MT and TT at M235T site in the ACI group was higher than that in the normal group,and the difference was statistically significant(P<0.05).The blood glucose level between the two groups carrying 2 different kinds of genotype showed no statistically significant difference (P >0.05 ).Conclusion No correlation is found among AGT gene T174M,M235T polymorphism,blood glucose level and atherosclerotic cerebral infarction;hyperglycemia is one of the risk factors of atherosclerotic cerebral infarction occurrence.
