Clinical significance of C-reactive protein and procalcitonin in chronic obstructive pulmonary disease with acute exacerbation
10.3760/cma.j.issn.1008-6706.2014.23.019
- VernacularTitle:急性加重期慢性阻塞性肺疾病患者血清C 反应蛋白及降钙素原水平变化及意义
- Author:
Ruiliang YANG
;
Shuying LI
;
Yikai NU
- Publication Type:Journal Article
- Keywords:
Pulmonary disease,chronic obstructive;
C-reactive protein;
Procalcitonin;
Calcitonin gene-related peptide
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(23):3569-3570
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore clinical significance of C-reactive protein( CRP) and procalcitonin ( PCT) in chronic obstructive pulmonary disease( COPD) with acute exacerbation.Methods Included 120 COPD patients with acute exacerbations,and at the same time,according to the random number table method,120 COPD patients with stable were extracted, all respondents were given corresponding symptomatic support treatment, observation before treatment,after treatment,the 1d,7d,14d patients serum levels of CRP was associated with change PCT level. Results Compared with before treatment, after treatment, the serum levels of CRP of COPD patients with acute exacerbation of at 1d,7d,14d was associated with a decline in PCT level, different time points more statistically significant difference( all P<0.05);Compared with patients with stable,before treatment,after treatment,the 1d,7d serum levels of CRP[(12.32 ±6.59)mg/L,(9.05 ±3.31)mg/L,(7.31 ±2.31)mg/L,(4.45 ±1.54)mg/L]was associated with a high level of PCT[(0.34 ±0.05)μg/L,(0.26 ±0.04)μg/L,(0.18 ±0.04)μg/L,(0.10 ± 0.03)μg/L]were obvious,more statistically significant difference(all P<0.05);But after treatment,serum CRP was associated with differences in the level was no statistical comparison PCT significance ( P >0.05 ) .Conclusion COPD patients with acute exacerbation of serum CRP and early PCT significantly higher level,its level after treatment dropped significantly,joint observation CRP and serum PCT level can reflect COPD acute exacerbation issue of the inflammatory reaction.
