Establishment of a assessment model for the clinical efficacy of neoadjuvant chemotherapy in nasopharyngeal carcinoma
10.3969/j.issn.1671-8348.2014.32.004
- VernacularTitle:鼻咽癌新辅助化疗疗效预测模型的建立
- Author:
Jin QUAN
;
Ge WANG
;
Debing XIANG
;
He XIAO
- Publication Type:Journal Article
- Keywords:
nasopharyngeal neoplasms;
neoadjuvant chemotherapy;
predicting model
- From:
Chongqing Medicine
2014;(32):4283-4287
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a model to predict the clinical response of neoadjuvant chemotherapy for nasopharyngeal car‐cinoma ,and provide basis for the individual treatment .Methods The clinical data of 63 cases of advanced nasopharyngeal carcinoma patients who have received neoadjuvant chemotherapy in the past 2 years were analyzed retrospectively .Univariate and multivariate analyses were performed using the Logistic analyses to identify efficacy factors .Results The response rate in nasopharyngeal tumor and lymph node metastasis were 39 .7% and 50 .8% ,respectively .Single factor analysis showed that patients with no distant metas‐tasis ,cranial nerve inviolated ,EBV negative and high expression of Ki67 were more sensitive to therapy .Logistic analysis showed that the influencing factors for the effect of the new chemotherapy include :distant metastasis ,cranial nerve inviolated and EBV . Thus ,the prediction model would be:Logit= -0 .470 -2 .863 × distant metastasis + 1 .328 × cranial nerve invasion+ 3 .639 × EBV ,its sensitivity ,specificity ,positive predictive value and negative predictive value were 79 .4% ,82 .8% ,84 .4% and 77 .4% . Conclusion The distant metastasis ,cranial nerve invasion and EBV infection were important predictive factors for neoadjuvant chemotherapy of nasopharyngeal carcinoma .This model could be used to predict the response of patients with nasopharyngeal carci‐noma .
