Efficacy analysis of four antiviral solutions for chronic hepatitis B treatment

VernacularTitle:4种抗病毒方案治疗慢性乙型肝炎的疗效分析
Author: Jianhui CHEN ; Xiao WANG ; Ni XIAO ; Bin YU ; Jun ZHOU
Publication Type:Journal Article
Keywords: chronic hepatitis B; lamivudine; adefovir dipivoxil; entecavir
From: International Journal of Laboratory Medicine 2014;(22):3040-3041
CountryChina
Language:Chinese
Abstract: Objective To investigate the efficacy of four antiviral solutions for chronic hepatitis B (CHB) treatment .Methods 240 cases of patients with CHB were selected ,divided into four groups (group A ,group B ,group C and group D) ,and treated with lamivudine ,adefovir dipivoxil ,adefovir dipivoxil/lamivudine ,and entecavir ,respectively .The recovery rates of ALT and AST ,HBV DNA and its negative conversion rates ,and HBeAg/HBeAb conversion rates of the four groups were compared respectively after 12 ,24 and 48 weeks treatment .And the YMDD mutation rates were compared after 48 weeks treatment .Results The recovery rates of ALT and AST ,HBV DNA and its negative conversion rates ,HBeAg/HBeAb conversion rates ,HBeAg/HBeAb conversion rates of group C and group D were significantly better than those of group A and group B (P<0 .05) .Conclusion The antiviral so‐lutions of adefovir dipivoxil/lamivudine and entecavir are two kinds of rational treatment .