Efficacy analysis of four antiviral solutions for chronic hepatitis B treatment
10.3969/j.issn.1673-4130.2014.22.015
- VernacularTitle:4种抗病毒方案治疗慢性乙型肝炎的疗效分析
- Author:
Jianhui CHEN
;
Xiao WANG
;
Ni XIAO
;
Bin YU
;
Jun ZHOU
- Publication Type:Journal Article
- Keywords:
chronic hepatitis B;
lamivudine;
adefovir dipivoxil;
entecavir
- From:
International Journal of Laboratory Medicine
2014;(22):3040-3041
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of four antiviral solutions for chronic hepatitis B (CHB) treatment .Methods 240 cases of patients with CHB were selected ,divided into four groups (group A ,group B ,group C and group D) ,and treated with lamivudine ,adefovir dipivoxil ,adefovir dipivoxil/lamivudine ,and entecavir ,respectively .The recovery rates of ALT and AST ,HBV DNA and its negative conversion rates ,and HBeAg/HBeAb conversion rates of the four groups were compared respectively after 12 ,24 and 48 weeks treatment .And the YMDD mutation rates were compared after 48 weeks treatment .Results The recovery rates of ALT and AST ,HBV DNA and its negative conversion rates ,HBeAg/HBeAb conversion rates ,HBeAg/HBeAb conversion rates of group C and group D were significantly better than those of group A and group B (P<0 .05) .Conclusion The antiviral so‐lutions of adefovir dipivoxil/lamivudine and entecavir are two kinds of rational treatment .