Chromosome karyotype analysis of amniotic fluid cells of 1 466 pregnant women in Yangzhou
10.3969/j.issn.1673-4130.2014.22.016
- VernacularTitle:扬州地区1466例孕妇羊水细胞染色体核型分析
- Author:
Jian CHEN
;
Guijiang XU
- Publication Type:Journal Article
- Keywords:
amniotic fluid;
cell culture;
chromosome karyotype analysis
- From:
International Journal of Laboratory Medicine
2014;(22):3042-3043
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinic value of chromosome karyotype analysis of amniotic fluid cells in prenatal diagnosis . Methods 1 466 cases of pregnant women who had the prenatal diagnosis indexes were selected ,and their amniotic fluid specimens were collected through amniocentesis guiding by type‐B ultrasonic around the 16th to 24th week .Amniotic fluid cells were gained after a successful cell culture .G banding was used for the karyotype analysis of amniotic fluid cells .Results The one‐time success rate of cultivation for amniotic fluid cells was 99 .8% .In 1 466 cases of pregnant women ,there were 16 cases of abnormal karyotype polymorphism (including 12 cases of trisomy 21 ,1 case of trisomy 18 ,and 3 cases of Chromosome abnormalities) and 3 cases of chromosomal polymorphism .Conclusion The chromosome karyotype analysis of amniotic fluid cell is still an irreplaceable test in prenatal diagnosis .
