Effects of Dengzhanhua Capsule on Kidney Tissue Inflammatory Cytokines in Chronic Renal Failure Rats
10.3969/j.issn.1005-5304.2014.12.018
- VernacularTitle:灯盏花胶囊对慢性肾功能衰竭大鼠肾组织炎症因子的影响
- Author:
Yibin DU
;
Xiao WU
;
Feng WU
;
Qi LI
;
Kunyang ZHANG
;
Yanrui DUAN
;
Chuqiao XIE
;
Liqun HE
- Publication Type:Journal Article
- Keywords:
chronic renal failure;
microinflammation;
renal fibrosis;
Dengzhanhua;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(12):63-65
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Dengzhanhua Capsule on kidney tissue inflammatory cytokines in chronic renal failure rats;To explore its possible mechanism for the efficacy in chronic renal failure. Methods Sixty SD rats were randomly divided into normal control group, model group, benazepril group and Dengzhanhua group, 15 rats in each group. Chronic renal failure rat model was established by Platt 5/6 nephrectomized. Benazepril (0.29 mg/100 g) was given to rats in the benazepril group by gastrogavage. Dengzhanhua Capsule (0.3 g/100 g) was given to rats in the Dengzhanhua group by gastrogavage. Normal saline was given to rats in the normal group and the model group by gastrogavage. The whole treatment period was twelve weeks. Expressions of TGF-β1 and PAI-1 were determined by semi-quantitative RT-PCR after treatment. Concentrations of kidney tissue inflammatory cytokines IL-6 and TNF-α were determined by ELISA. Results Expressions of TGF-β, PAI-1 and IL-6, TNF-αin benazepril group and Dengzhanhua group were significantly lower than those in model group (P<0.05). Compared with benazepril group, it was significantly lower in Dengzhanhua group (P<0.05). Conclusion Dengzhanhua Capsule can reduce kidney tissue inflammatory in chronic renal failure rats, and inhibit renal fibrosis.
