Evaluation of diffusion weighted imaging after contrast in characterizing breast tumors

VernacularTitle:MRI 增强后扩散加权成像鉴别乳腺良恶性肿瘤临床应用研究
Author: Juan HUANG ; Junzhang TIAN ; Guihua JIANG ; Shaoqing ZENG ; Xiaofen MA ; Wuming LI
Publication Type:Journal Article
Keywords: breast carcinoma; diffusion weighted imaging; apparent diffusion coefficient; gadolinium-DTPA
From: Journal of Practical Radiology 2014;(11):1831-1834
CountryChina
Language:Chinese
Abstract: Objective To evaluate the effect of intravenous administration of gadolinium-DTPA on diffusion weighted imaging (DWI)of breast lesions and apparent diffusion coefficient(ADC)values,and to evaluate the diagnostic performance of post-contrast ADC for differentiating benign from malignant lesions in breast.Methods Thirty-eight histopathologically-confirmed breast lesions were analyzed.We examined the signal to noise ratio(SNR)of normal breast tissue and lesions and evaluated the contrast to noise ratio(CNR)of each lesion.We also assessed the relation between pre-and post-contrast ADC values.Results SNRs and CNRs of DWI before and after contrast were not significantly different.The mean post-contrast ADC values for malignant lesions significantly decreased after contrast injected (mean of -1 1.6%),while ADC values in the benign lesions were not significantly different before and after contrast.Conclusion Post-contrast ADC values may be a better indicator of potential breast tumors than pre-contrast ADC values.