Study on Pharmacokinetics of Levofloxacin Polymorphs in Rats
10.3870/yydb.2014.11.002
- VernacularTitle:左氧氟沙星4种晶型的大鼠体内药动学研究
- Author:
Yuanyuan WU
;
Guimin JIN
;
Guanhua DU
;
Yang LYU
;
Guidong DAI
- Publication Type:Journal Article
- Keywords:
Levofloxacin;
Polymorphs;
Pharmacokinetics;
HPLC
- From:
Herald of Medicine
2014;(11):1407-1411
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the pharmacokinetics difference of levofloxacin polymorphs in rats, evaluate the advantageous medical polymorph,and explore the effects of different polymorphs on clinical medicine. Methods Four crystal forms of levofloxacin were administered intragastrically to rats,and high performance liquid chromatography( HPLC)was used to measure the contents of levofloxacin in rat plasma. The pharmacokinetic parameters were calculated and compared Results After a single oral dose,the peak plasma concentration(Cmax)of crystal forms ofⅠ,Ⅱ,ⅢandⅣof levofloxacin was 6. 984,9. 692,9. 405,6.424 mg·L-1;the time to peak(tmax)was 0.6,0.9,1.0,1.0 h;the half-life(t1/2)was 4.207,2.97,4.857,1.695 h;theareaunderthecurve(AUC0→12h)was31.478,42.385,32.406,31.636mg·h·L-1. Conclusion Thereisnostatistically significant difference in pharmacokinetic parameters. However,compared with other crystal forms,plasma concentration of crystal form II is higher and maintained longer. Therefore,crystal form II of levofloxacin is an advantageous polymorph for medicine.
