Effect of Lincomycin on the Intestinal Mucosa Barrier of Mice
10.3870/yydb.2014.11.008
- VernacularTitle:林可霉素对小鼠肠道屏障作用的影响
- Author:
Kaixian DU
;
Yu LUO
;
Yan ZHANG
;
Yan DONG
- Publication Type:Journal Article
- Keywords:
Lincomycin;
Intestinal flora;
Intestinal mucosal barrier
- From:
Herald of Medicine
2014;(11):1431-1433
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of lincomycin hydrochloride on the intestinal mucosal barrier of mice. Methods A total of 24 mice were equally and randomly divided into normal control group and model group. Mice in the model group were administered with 8 mg · kg-1 · d-1 of lincomycin hydrochloride through gastric lavage for 3 days to establish the model of intestinal mucosa injury and alteration of intestinal flora in mice. The intestinal flora was tested,bacterial translocation was analyzed,and mucosa permeability was determined by measuring diamine oxidase( DAO)in plasma. Results Lincomycin hydrochloride led to alteration of intestinal flora in mice after oral administration for three days in mice. The aerobes translocation rate was 16. 7% and 52. 3% in the normal and model groups,respectively(P〈0. 01). The anaerobes translocation rate was 8. 3% and 68. 2% in the normal and model groups,respectively(P〈0. 01). The plasma concentration of diamine oxidase was increased from(2. 08±0. 05)mg·mL-1 in the normal group to(7. 18±0. 10)mg·mL-1 in the model group(P〈0. 01). Conclusion Lincomycin hydrochloride damages intestinal mucosal barrier in mice.
