Role of procalcitonin in diagnosis and antibiotics therapy of community acquired pneumonia
10.3969/j.issn.1006-5725.2014.20.011
- VernacularTitle:降钙素原在诊断社区获得性肺炎和指导抗生素应用中的价值
- Author:
Jiaxin SHI
;
Jiashu LI
- Publication Type:Journal Article
- Keywords:
Procalcitonin;
Community acquired pneumonia;
Diagnosis;
Antibiotics
- From:
The Journal of Practical Medicine
2014;(20):3236-3238
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of procalcitonin (PCT) in diagnosis and antibiotics therapy of community acquired pneumonia (CAP). Methods A total of 296 patients with CAP and 221 patients with other diseases were included. PCT levels between CAP patients and non-CAP patients, aged and non-aged CAP patients were analyzed. SPSS19.0 was used to make ROC, and the maximum Youden index to determine the optimal cutoff value, the corresponding sensitivity (SEN) and specificity (SPE). Results PCT levels in CAP patients were significantly higher than those in non-CAP (P<0.05). The diagnostic value of PCT in CAP was as follows: the area under the curve (AUC) was 0.67, the optimal cutoff value 0.055 ng/mL and the SEN and SPE were 0.55 and 0.77 respectively. For aged CAP patients, the values were 0.63, 0.055 ng/mL, 0.53 and 0.73 respectively and for non-aged CAP patients, the values were 0.73, 0.085 ng/mL, 0.53 and 0.90 respectively. The days of treatment in PCT-guided antibiotics therapy group were greatly less than those in clinical and radiology-guided antibiotics therapy (P<0.05), while there was no difference on relapse (P>0.05). Conclusion PCT has a high value in diagnosis and antibiotics therapy of CAP.
