Allogeneic hematopoietic stem cell transplantation for the treatment of chronic myeloid leukemia in blast crisis
10.3760/cma.j.issn.1009-9921.2013.06.004
- VernacularTitle:异基因造血干细胞移植在急变期慢性粒细胞白血病治疗中的应用
- Author:
Lanping XU
;
Xiaojun HUANG
- Publication Type:Journal Article
- Keywords:
Leukemia,myeloid,chronic;
Blast crisis;
Allogeneic hematopoietic stem cell transplantation
- From:
Journal of Leukemia & Lymphoma
2013;22(6):330-335
- CountryChina
- Language:Chinese
-
Abstract:
The treatment for chronic myeloid leukemia is still a challenge,at present.Tyrosine kinase inhibitors can partially control chronic myeloid leukemia in blast crisis (CML-BC),but the effect is not durable.Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only way that can cure CML-BC.This paper presents a review of the treatment before allo-HSCT for CML-BC,the selection of condition regimen,donor and hematopoietic stem cell,the monitoring of MRD post-transplant,the prophylaxis and intervention of relapse.
