Genetic Polymorphism in Proteins of the Complement System.
10.4285/jkstn.2016.30.2.59
- Author:
Hyori KIM
1
;
Dobeen HWANG
;
Jungwon HAN
;
Hwa Kyoung LEE
;
Won Jun YANG
;
Junyeong JIN
;
Ki Hyun KIM
;
Sang Il KIM
;
Duck Kyun YOO
;
Soohyun KIM
;
Junho CHUNG
Author Information
1. Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- Publication Type:Review
- Keywords:
Complement system proteins;
Genetic polymorphism;
Autoimmune diseases
- MeSH:
Antibodies;
Autoimmune Diseases;
Complement System Proteins*;
Immune System;
Phagocytes;
Polymorphism, Genetic*
- From:The Journal of the Korean Society for Transplantation
2016;30(2):59-68
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The complement system is a part of the innate immune system that potentiates the ability of antibodies and phagocytic cells to clear microbes and damaged cells. The complement system consists of a number of proteins circulating as inactive precursors. It is stimulated mainly by three pathways: the classical pathway, the alternative pathway, and the lectin pathway. There are many genetic polymorphisms in this system, which can over-activate the immune system. In this study, we collected the polymorphisms reported to over-activate complement cascades that affect the immune system and induce autoimmune diseases.
