Expression of muscarinic cholinergic receptor 3 in small cell lung cancer and its clinical sig-nificance
10.13315/j.cnki.cjcep.2014.11.009
- VernacularTitle:小细胞肺癌中M3R的表达及意义
- Author:
Hua HE
;
Ailing MA
;
Shuxiang ZHANG
- Publication Type:Journal Article
- Keywords:
lung neoplasm;
small cell lung cancer;
muscarinic cholinergic receptor 3;
immunohistochemistry;
prognosis
- From:
Chinese Journal of Clinical and Experimental Pathology
2014;(11):1237-1241
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expression of muscarinic cholinergic receptor 3 (M3R) in small cell lung cancer (SCLC) and the correlation between it and clinical characteristics of SCLC. Methods The M3R expression was examined in 60 SCLC patients ad-mitted using immunohistochemistry. The patients were evaluated by clinical history, physical examination and chest CT. Survival time was got through telephone follow-up. Results The M3R expression in primary SCLC tissues was higher than that in normal lung tis-sues. The M3R expression had no difference between limited-disease and extensive-disease of SCLC. There was no correlation between M3R expression and age, gender, lymph node metastasis. The M3R expression was significantly correlated with smoking history. The survival time of M3R negative patients was longer than that of M3R positive patients in Kaplan-Meier survival curve. Conclusion The M3R expression in primary SCLC tissues was higher than that in normal lung tissues. M3R expression had some correlation with prog-nosis of SCLC patients.
