Expression and significance of autophagic gene Beclin 1 and MAP1 LC3 protein in cutaneous malignant melanoma

VernacularTitle:皮肤黑色素瘤中自噬基因 Beclin 1和 MAP1 LC3的表达及意义
Author: Yuanting SU ; Congjun JIANG ; Ligao WU ; Shiwu WU ; Ruzhi ZHANG ; Huiling JIN
Publication Type:Journal Article
Keywords: cutaneous malignant melanoma; autophagic genes; immunohistochemistry
From: Chinese Journal of Clinical and Experimental Pathology 2014;(11):1247-1250
CountryChina
Language:Chinese
Abstract: Purpose To detect the expression of autophagic genes Beclin 1 and MAP1LC3 in cutaneous malignant melanoma and to ex-plore the relationship between autophagia and malignant melanoma. Methods 85 cases of speicmens including normal skin tissue, in-tradermal nevi, radial growth phase melanomas, vertical growth phase melanomas, and metastatic melanoma were collected, and the protein expression of Beclin 1 and MAP1LC3 were evaluated by immunohistochemistry of SP methods. Results The Beclin 1 and MAP1LC3 expression were pretended to be 100% in normal skin tissue, and they were declined to 85% and 95% in intradermal nevi, 58% and 50% in radial growth phase melanomas, 49. 5% and 44. 4% in vertical growth phase melanomas, both of 17% in melanoma metastases (P<0. 05). Conclusion Beclin 1 and MAP1LC3 autophagic gene expression were significantly decreased with tumor pro-gression, as well as was correlated with conventional histopathologic prognostic factors.